Category Archives: News

MedPage TodayHas Pendulum Swung Too Far on Bisphosphonates?MedPage TodayMonitoring via conventional radiographs, DXA scans, and/or advanced imaging is one way to determine that point for individual patients, Saag suggested. He proposed bisphosphonate “sabbaticals,” defined as an extended stoppage of therapy, as opposed to … Source:: DXA Feed       

MedPage TodayDenosumab more effective than risedronate in glucocorticoid-induced osteoporosisHealioAdults with a history of glucocorticoid-induced osteoporosis assigned to therapy with the monoclonal antibody denosumab experienced a greater increase in bone mineral density at the lumber spine and total hip at 12 months vs. similar patients assigned …Benefits, Drawbacks to Denosumab Tx in ESRDMedPage Todayall 2 news … Continue reading →

Medical XpressIn Europe, CHMP missed an opportunity for osteoporosis patients at high risk of fractureMedical XpressProfessor Cyrus Cooper, president of IOF, stated: “It is undisputed among experts and patients alike that there is a critical need for effective treatments for those who are at high risk of sustaining serious and life-threatening fractures due to …and … Continue reading →

Fracture liaison service increases BMD testing, osteoporosis treatmentHealioAdults with osteoporosis who received care from a fracture liaison service program were more likely to undergo bone mineral density testing and initiate and adhere to osteoporosis treatment vs. adults receiving usual care, according to study findings … Source:: Osteoporosis Feed       

Radius Health Initiates Phase 3 Clinical Trial of Abaloparatide Injection for the Treatment of Male OsteoporosisGlobeNewswire (press release)The primary endpoint of the male osteoporosis study is change in lumbar spine bone mineral density (BMD) at 12 months compared with placebo. The randomized, double-blind, placebo-controlled trial will enroll approximately 225 men with osteoporosis … Source:: Osteoporosis … Continue reading →

Prevention.com6 Exercises You Shouldn’t Do if You Have OsteoporosisPrevention.comAs with osteoporosis, there’s an “abnormally thin and weakened skeleton that is more susceptible to fractures or breaks, these fractures can result in severe morbidity and even mortality,” he says. So, you’ll really need to avoid any exercise moves or … Source:: Osteoporosis Feed       

EMA Panel Rejects Abaloparatide for OsteoporosisMedscapeRadius has just reported more data from this trial, at the recent ENDO 2018 meeting. In follow-up of ACTIVExtend, sequential treatment with abaloparatide followed by alendronate led to greater increases in bone mineral density (BMD) in women with … Source:: Osteoporosis Feed       

Endocrinology AdvisorType 2 Diabetes Associated With Increased Fracture Risk in Postmenopausal WomenEndocrinology AdvisorPatients with type 2 diabetes had more prevalent fractures and more prevalent major osteoporotic fracture compared with those without diabetes. Type 2 diabetes may be associated with an increased risk for a major osteoporotic fracture (MOF) in … Source:: Osteoporosis Feed       

Endocrinology AdvisorGreater Bone Formation With Teriparatide vs Zoledronic Acid in OsteoporosisEndocrinology AdvisorTreatment for osteoporosis with teriparatide is associated with greater bone formation than treatment with zoledronic acid, according to a study published in the Journal of Bone and Mineral Research.1. A previously conducted phase 4 study in ambulatory … Source:: Osteoporosis Feed       

NasdaqRadius Health Announces Positive Data on Lead Drug TymlosNasdaqRadius Health, Inc . RDUS announced positive results from the phase III study, ACTIVExtend, at ENDO 2018, the Endocrine Society’s 100th Annual Meeting and Expo in Chicago. The phase III study, ACTIVE (Abaloparatide Comparator Trial In Vertebral … Source:: Osteoporosis Feed       

Science DailyAbsence of key protein, TTP, rapidly turns young bones oldScience DailyThe research results could have a profound impact on the management of bone health in the elderly, a population at higher risk of osteoporosis and periodontitis. “TTP is the brake on the system. Without it, inflammation and bone loss would go unchecked …and more … Continue reading →

No increased fracture risk identified with sarcopeniaHealioParticipants underwent DXA measurements to assess femoral neck BMD, as well as lean mass, appendicular lean mass and skeletal muscle index, with low muscle index defined as skeletal muscle index up to 7.25 kg/m² for men and 5.67 kg/m² for women. The … Source:: DXA Feed       

Rheumatology AdvisorCost-Effectiveness of Community-Based Screening for Osteoporotic Fracture RiskRheumatology AdvisorResearchers used the FRAX risk assessment tool to calculate a 10-year hip fracture probability from participants who were randomly assigned to the screening group. Participants with a sufficiently high risk for fracture underwent dual-energy X-ray …and more Source:: DXA Feed       

Rheumatology AdvisorAbaloparatide Treatment Evaluated in Elderly Women With OsteoporosisRheumatology AdvisorTreatment with abaloparatide is associated with significantly increased BMD of the lumbar spine and proximal femur in women older than 80 years. In women older than 80 years, treatment with abaloparatide is associated with significantly increased bone … Source:: Osteoporosis Feed       

Nursing TimesScreening for fracture risk in older women is ‘highly cost-effective intervention’Nursing TimesStudy authors. The researchers examined results from a large randomised controlled trial, called SCOOP, which involved 12,483 women aged 70 to 85 years. It compared a screening programme using the FRAX risk assessment calculator in addition to bone … Source:: DXA Feed       

Oncology Nurse AdvisorCalcitriol May Improve Hormone-Therapy Induced Osteoporosis in Breast Cancer SurvivorsOncology Nurse AdvisorCalcitriol and weight-bearing exercise were both found to be feasible and well-tolerated interventions among patients with breast cancer experiencing cancer treatment-induced bone loss (CTIBL), but only calcitriol was associated with significantly …and more Source:: Osteoporosis Feed       

MedscapeRoutine CT Scans Can Pinpoint Patients at High Risk of FractureMedscapeTaking a simple measurement of bone quality during routine computed tomography (CT) scans of the chest or abdomen may help identify older patients, over 65 years, at high risk for fragility fracture over approximately 6 years of follow-up, a new … Source:: DXA Feed       

Osteoporosis: An Avoidable CrisisScientific AmericanBut somehow I never realized that most of this death and disability can be attributed to the steady skeletal erosion of osteoporosis, a disease that, it turns out, is pretty darn treatable. Unfortunately, false ideas like mine have led us to a … Source:: Osteoporosis Feed       

Denosumab May Increase BMD in Women With Primary HyperparathyroidismEndocrinology AdvisorA significant increase in bone mineral density was more frequent in women with primary hyperparathyroidism than in women with primary osteoporosis. In older women with primary hyperparathyroidism (PHPT)-related osteoporosis, treatment with denosumab … Source:: Osteoporosis Feed       

Medical XpressCould sugar chains be the answer to bone growth in osteoporosis?Medical XpressThis is the first time that these sugar chains have been connected to bone growth and could pave the way for new investigations into possible future treatments for osteoporosis, where bone strength is a particular issue. Professor Paul Genever, from …Scientists discover new … Continue reading →

Scientists discover new link between bone cells and blood sugar …EurekAlert (press release)Bone cells do not just form new bone, they also influence the blood sugar level. Leuven scientists have now discovered a new mechanism that controls this link. The metabolism of bone cells determines how much sugar they use; if the bone cells consume … Continue reading →

Could sugar chains be the answer to bone growth in osteoporosis?EurekAlert (press release)Scientists at the University of York have shown that altering the structure of sugar chains on the surface of stem cells could help promote bone growth in the body. The discovery could have important implications for future treatments of osteoporosis … Source:: Osteoporosis … Continue reading →

Newly identified adipokine associated with bone density in type 2 diabetesHealioThey also underwent DXA measurements to assess BMD at the lumbar spine, femoral neck and hip. Patients were stratified into three groups based on DXA T-score: normal BMD (n = 148), osteopenia (n = 94) and osteoporosis (n = 33). Researchers used linear … Source:: … Continue reading →

New York TimesA Perfect Storm for Broken BonesNew York TimesAs the population over 50 swells, fewer adults at risk of advanced bone loss and fractures are undergoing tests for bone density, resulting in a decline in the diagnosis and treatment of osteoporosis, even for people who have already broken bones. If … Source:: Osteoporosis Feed … Continue reading →

Teriparatide therapy beneficial in pregnancy- and lactation-induced osteoporosisHealioWomen with pregnancy- and lactation-induced osteoporosis who experienced multiple vertebral fractures saw a 15% improvement in bone mineral density at the lumbar spine after 1 year of daily teriparatide therapy, as well as improvements in bone turnover … Source:: Osteoporosis Feed