Title: Bone Density Increase While on ‘Drug Holiday”


A 69 year old PM woman with history of low bone density has completed 5 years of  bisphosphonate therapy and two years of a ‘drug holiday’. She continued with her calcium 500mgs and vitamin D 10 mcg/day.
Repeat bone density with Discovery A Hologic densitometer is performed and reveals a surprising increase of 4% in bone density, beyond least significant change:




  • Should there be a significant increase of 4% over a 2-year period in which the patient was on a ‘drug holiday’?
  • What questions should we ask ourselves about this scan?
  • Is there anything in the region of interest  or outside the region of interest that should not be visible?
  • Should we repeat the bone density?


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